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Fence Methods to Genetic Application(2pm,Tuesday, June 23 , 2015)
发表时间:2015-05-22 阅读次数:596次

Time: 2pm,Tuesday, June 23 , 2015

 

Venue: Room 2201, East Guanghua Tower, Fudan University

 

Speaker: Dr. Thuan Nguyen (Oregon Health & Science University)

 

Title: Fence Methods to Genetic Application

 

Abstract: Model search strategies play an important role in finding simultaneous susceptibility genes that are associated with a trait. More particularly, model selection via the information criteria, such as the BIC with modifications, has received considerable attention in quantitative trait loci (QTL) mapping. However, such modifications often depend upon several factors, such as sample size, prior distribution, and the type of experiment, e.g., backcross, intercross. These changes make it difficult to generalize the methods to all cases. The fence method avoids such limitations with a unified approach, and hence can be used more broadly. In this talk, the method is studied in the case of backcross experiments (BE). In particular, a variation of the fence, called restricted fence (RF), is applied to BE, and its performance is evaluated and compared with the existing methods. Furthermore, we incorporate our recently developed strategy for model selection with incomplete data, known as the E-MS algorithm, with the RF to address the common missing value concerns in BE. Our study reveals some interesting findings in association with the missing data mechanisms. The proposed method is illustrated with a real data analysis involving QTL mapping for an agricultural study on barley grains.

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