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Lei Xue
Published:2013-06-05 Hits:2088

 

 Lei Xue

Principle Investigator
School of Life Sciences, Fudan University
Email: lxue@fudan.edu.cn
Office Phone: 86-21-55664910
Homepage: N/A

 

Background:

2000 –2005  Ph.D. degree, Neurobiology, Fudan University, P.R. China

1996 - 2000  B.S. degree, Genetics, Fudan University, P.R. China

 

Awards:

One Thousand Plan Global Expert Recipient

Shanghai Pujiang Talent Plan Recipient

 

Research:

We study the mechanisms of synaptic transmission in the central nervous system, mainly focused on the kinetics regulation of exo-endocytosis, synaptic plasticity and the modeling of vesicle recylcing. Projects include:1) the mechanisms of calcium controlled exo-endocytosis; 2)calcium and exo-endocytosis affected synaptic plasticity;3) The modeling of neurotransmitter release and vesicle recycling.

 

Representative Publications:

1. Xue L#, Sheng J, Wu XS, Wu W, Luo FJ, Shin Wonchul, Chiang HC, and Wu LG#. (2013). Most vesicles in a central nerve terminal participate in recycling. Journal of Neuroscience2013 May 15;33(20):8820-6. (#: corresponding author)

2. Xu J, Luo F, Zhang Z, Xue L, Wu XS, Chiang HC, Shin W and Wu LG.(2013). SNARE Proteins Synaptobrevin, SNAP-25, and Syntaxin Are Involved in Rapid and Slow Endocytosis at Synapses. Cell reports, 02 May 2013, doi:10.1016/j.celrep.2013.03.010

3. Xue L, Zhang Z, McNeil B, Luo FJ, Wu XS, Sheng JS and Wu LG. (2012). Voltage-dependent calcium channels at the plasma membrane, but not vesicular channels, couple exocytosis to endocytosis. Cell reports, 1 (6) : 632-638.

4. Sheng JS,He L, Zheng H, Xue L, Luo FJ, Shin W, Sun T and Wu LG. (2012). Calcium-channel number critically influences synaptic strength and plasticity at the active zone. Nature Neuroscience, 15(7), 998–1006.

5. Xue L, McNeil BD, Wu XS, Luo FJ, He L and Wu LG. (2012). A Membrane Pool Retrieved via Endocytosis Overshoot at Nerve Terminals: A Study of Its Retrieval Mechanism and Role. Journal of Neuroscience, 2012 Mar 7; 2(10):3398-404.

6. Xue L and Mei YA. (2011). Synaptic vesicle cycling at the calyx of the Held.  Acta Pharmacological Sinica, 2011 Mar;32(3):280-7.

7. Xue L and Wu LG. (2010). Post-tetanic potentiation is caused by two signaling mechanisms affecting quantal size and quantal content. Journal of Physiology (Lond.)  4987–4994.

8. He L*, Xue L*, Xu J, McNeil B, Bai L, Melicoff E, Adachi R and Wu LG. (2009) Compound vesicle fusion increases quantal size and potentiates synaptic transmission, Nature, 459(7243):93-7. (*: Equal first author)

9. Xue L#, Zhang F, Chen X, Lin J, Shi J. PDZ Protein Mediated Activity-Dependent LTP/LTD Developmental Switch at Rat Retinocollicular Synapses. (2010). American Journal of Physiology, Cell Physiology, 298(6):C1572-82. (#: First author and corresponding author)

10. Wu XS, McNell B, Xu J, Fan JM, Xue L, Melicoff E, Adachi R, Bai L and Wu LG. (2009). Ca2+ and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal. Nature Neuroscience, 12(8):1003-10.

11. Wu XS, Xue L, Mohan R, Paradiso K, Gillis KD, Wu LG. (2007) The origin of quantal size variation: vesicular glutamate concentration plays a significant role. Journal of Neuroscience, 27(11):3046-56.

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