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Lei Xue
Published:2013-06-05 Hits:2140


 Lei Xue

Principle Investigator
School of Life Sciences, Fudan University
Office Phone: 86-21-55664910
Homepage: N/A



2000 –2005  Ph.D. degree, Neurobiology, Fudan University, P.R. China

1996 - 2000  B.S. degree, Genetics, Fudan University, P.R. China



One Thousand Plan Global Expert Recipient

Shanghai Pujiang Talent Plan Recipient



We study the mechanisms of synaptic transmission in the central nervous system, mainly focused on the kinetics regulation of exo-endocytosis, synaptic plasticity and the modeling of vesicle recylcing. Projects include:1) the mechanisms of calcium controlled exo-endocytosis; 2)calcium and exo-endocytosis affected synaptic plasticity;3) The modeling of neurotransmitter release and vesicle recycling.


Representative Publications:

1. Xue L#, Sheng J, Wu XS, Wu W, Luo FJ, Shin Wonchul, Chiang HC, and Wu LG#. (2013). Most vesicles in a central nerve terminal participate in recycling. Journal of Neuroscience2013 May 15;33(20):8820-6. (#: corresponding author)

2. Xu J, Luo F, Zhang Z, Xue L, Wu XS, Chiang HC, Shin W and Wu LG.(2013). SNARE Proteins Synaptobrevin, SNAP-25, and Syntaxin Are Involved in Rapid and Slow Endocytosis at Synapses. Cell reports, 02 May 2013, doi:10.1016/j.celrep.2013.03.010

3. Xue L, Zhang Z, McNeil B, Luo FJ, Wu XS, Sheng JS and Wu LG. (2012). Voltage-dependent calcium channels at the plasma membrane, but not vesicular channels, couple exocytosis to endocytosis. Cell reports, 1 (6) : 632-638.

4. Sheng JS,He L, Zheng H, Xue L, Luo FJ, Shin W, Sun T and Wu LG. (2012). Calcium-channel number critically influences synaptic strength and plasticity at the active zone. Nature Neuroscience, 15(7), 998–1006.

5. Xue L, McNeil BD, Wu XS, Luo FJ, He L and Wu LG. (2012). A Membrane Pool Retrieved via Endocytosis Overshoot at Nerve Terminals: A Study of Its Retrieval Mechanism and Role. Journal of Neuroscience, 2012 Mar 7; 2(10):3398-404.

6. Xue L and Mei YA. (2011). Synaptic vesicle cycling at the calyx of the Held.  Acta Pharmacological Sinica, 2011 Mar;32(3):280-7.

7. Xue L and Wu LG. (2010). Post-tetanic potentiation is caused by two signaling mechanisms affecting quantal size and quantal content. Journal of Physiology (Lond.)  4987–4994.

8. He L*, Xue L*, Xu J, McNeil B, Bai L, Melicoff E, Adachi R and Wu LG. (2009) Compound vesicle fusion increases quantal size and potentiates synaptic transmission, Nature, 459(7243):93-7. (*: Equal first author)

9. Xue L#, Zhang F, Chen X, Lin J, Shi J. PDZ Protein Mediated Activity-Dependent LTP/LTD Developmental Switch at Rat Retinocollicular Synapses. (2010). American Journal of Physiology, Cell Physiology, 298(6):C1572-82. (#: First author and corresponding author)

10. Wu XS, McNell B, Xu J, Fan JM, Xue L, Melicoff E, Adachi R, Bai L and Wu LG. (2009). Ca2+ and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal. Nature Neuroscience, 12(8):1003-10.

11. Wu XS, Xue L, Mohan R, Paradiso K, Gillis KD, Wu LG. (2007) The origin of quantal size variation: vesicular glutamate concentration plays a significant role. Journal of Neuroscience, 27(11):3046-56.

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