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Yuguo Yu
Published:2011-12-06 Hits:5023

Yuguo Yu 
Principle Investigator
Center for Computational Systems Biology, Fudan University
Office Phone: 86-21-55665560


2011-Pres.      Associate Research Scientist; Dept. Neurobiology, Yale Univ. School of Medicine
2005-2010      Post Doctoral Associate, Dept. Neurobiology, Yale University School of Medicine;
2001-2004      Post Doctoral Fellow, Center for the Neural Basis of Cognition, Carnegie Mellon University;
1998-2001      Ph.D. study, Research and Teaching Assistant, Department of Physics, Nanjing  University, China;


Neural circuits organise and transform sensory signals from the external physical world into signals in the brain. The biophysical mechanisms, computational rules and algorithms associated with single neurons and neural circuits are big mysteries that are unsolved. Our research goals include, but are not limited to the following topics.
1. Information representation (encoding and decoding) in neuronal circuitry.
2. Interfaces between the natural environment and adaptation/plasticity of neural structures.
3. The neuronal circuitry and synaptic mechanisms underlying learning and memory.
4. Neural dynamics and computational principles for neural computation and emergence of cognitive functions
5. Energy efficient brain signalling and the brain’s energy budget


Representative Publications:
1. Foust, A.J., Yu, Y.G., Popovic, M., Zecevic, D., and McCormick, D.A. Somatic Membrane Potential and Kv1 Channels Control Spike Repolarization in Cortical Axon Collaterals and Presynaptic Boutons. Journal of Neuroscience, 31(43):15490-15498 (2011).
2. Yu, Y.G., Maureira C., and D. A. McCormick. P/Q and N calcium channels play an important role in the electrophysiology of neocortical axons and synaptic terminals. Journal of Neuroscience, 30: 11858011869 (2010).
3. Yu Y.G., Shu Y., Duque A., Haider B., and McCormick D.A. Cortical Action Potential Back-propagation Explains Spike Threshold Variability and Rapid-Onset Kinetics. Journal of Neuroscience, 28: 7260-7272 (2008).
4. McCormick D.A., Shu Y., and Yu Y.G. Variability and rapid rate of rise at action potential threshold in cortical neurons results from spike initiation in the axon initial segment. Nature, 445: E1-E2 (2007).
5. Shu Y, Yu Y.G., Yang, J. and McCormick D.A. Selective control of cortical axonal action potentials by a slowly inactivating K+ current. Proceedings of the National Academy of Sciences (PNAS), 27: 11453-11458 (2007).
6. Yu, Y.G., Richard, R.D., and Lee, T.S. Preference of sensory neural coding for 1/f signals. Physical Review Letters, 94, 1081031-4 (2005)
7. Yu, Y. G., and Lee, T.S. Dynamical mechanisms underlying contrast gain control in single neurons. Physical Review E, 68, 0119011-0119017(2003).
8. Yu, Y. G., Wang, W., Wang, J.F., and Liu, F. Resonance-enhanced signal detection and transduction in Hodgkin-Huxley neuronal systems. Physical Review E, 63, 0219071-02190712, (2001).


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