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High Accuracy Protein Active Site Structures from Quantum Chemical Investigations of Spectroscopic Fingerprints (5月10日,周四,下午两点)
发表时间:2012-05-10 阅读次数:1103次

 

Title: High Accuracy Protein Active Site Structures from Quantum Chemical Investigations of Spectroscopic
         Fingerprints
 

Speaker: Yong Zhang         
              Associate Professor, Department of Chemistry, Chemical Biology, and Biomedical Engineering,
              Stevens Institute of Technology
 

Time:  2 pm, Thursday, May 10

 

Venue: Room 1801, East Guanghua Tower

 

Biography:

Dr. Zhang is the Director of the High Accuracy Computational Chemistry Group, where he is utilizing computer simulations incorporating quantum mechanics principles applied to chemical and biological processes to produce highly-accurate computer simulations of experimental medicines at the atomic level. Dr. Zhang's research interests include molecular design and mechanisms of metal-centered pharmaceuticals to combat cancer and neurodegenerative diseases, structural and functional investigation of novel metallobiomolecules involved in cellular regulation and signaling, molecular toxicities of environmentally hazardous compounds and design of protective and detoxifying agents, and structural and functional fingerprints of interesting molecules and biomolecules. His research is critical for pushing medical research and drug development to the next frontier.

Dr. Zhang has published many papers on computational analysis in the world's top chemical journals and other prestigious publications. He has been especially focused on the properties of HNO, a derivative of nitric oxide, NO, for which the fundamental research won the Nobel Prize in 1998. HNO has been shown to function in the regulatory process of vascular and neurological systems, and may help to treat victims of heart failure and hold back neurological damage after stroke. Dr. Zhang's research provides the first atomic level structural information of HNO bound in an important protein in the blood system, and reveals a unique HNO-protein interaction mode that may help understand many other HNO effects in biological systems.

 

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