中文  |  English
学术活动
当前位置 >> 首页 >> 学术活动 >> 2012
Neurobehavioural analysis of reinforcement and its relevance for alcohol abuse: results from the IMAGEN study (9月7日,周五,下午三点)
发表时间:2012-09-07 阅读次数:1495次

 

Title: Neurobehavioural analysis of reinforcement and its relevance for alcohol abuse: results from the IMAGEN study
 

Speaker: Gunter Schumann
              MRC-SGDP Centre, Institute of Psychiatry, King’s College, London


Time:   3 pm, Friday, Sep. 7

 

Venue: Room 1801, East Guanghua Tower, Handan Campus, Fudan University

 

Abstract:

Adolescent behaviour has been associated with alcohol abuse and dependence later in life. Individual variability in reinforcement processes (i.e., (impulsivity, novelty seeking, reward dependence) predict risk for addictions and describe motivations for drug use. Investigating how motivational and emotional cues affect individual variability in reinforcement behaviour at the genetic, neurobiological and cognitive levels might inform us about neurobehavioural mechanisms conferring risk for addictions, thus potentially maximizing the efficacy and efficiency of early interventions.

In the EC-FP6 Integrated Project IMAGEN, a European multicentric longitudinal gene x neuroimaging study, we aim to identify the genetic and neurobiological basis of individual variability in reinforcement behaviour and determine their predictive value for the development of addictions and other psychiatric disorders. Comprehensive behavioural and neuropsychological characterization, functional and structural neuroimaging and genome-wide association analyses of 2000 14-year-old adolescents at baseline are coupled with ongoing longitudinal follow-up at 16 and 19 years, and combined with functional genetics in animal and human models.

This lecture will focus on our recent investigations in 14 year-old adolescents of reinforcement mechanisms known to confer later risk for addictions. I will present structural and functional brain correlates of impulsivity (Schilling et al., Mol Psychiatry, in press) and describe how they relate to reward anticipation (Peters et al. Am J Psychiatry 2011) and risk taking (Schneider et al. Am J Psychiatry 2012) in substance abusing adolescents. I will discuss how gender and genetic factors influence neural mechanisms underlying novelty seeking and impulsivity (Nymberg et al., in review, in preparation), and how ADHD symptoms and early alcohol abuse are associated with distinct brain activity networks (Whelan et al., Nature Neuroscience, in press). Finally, I will discuss a novel mechanism underlying alcohol drinking behaviour, which has been discovered through translational research integrating animal, molecular and human gene x neuroimaging studies (Stacey et al. in preparation).


 

版权所有 复旦大学计算系统生物学中心 技术支持:维程互联
地址:上海市邯郸路220号