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Lecture Series (Ching-Po Lin, Bharat Biswal)
发表时间:2011-11-29 阅读次数:1155次

Seminar 1

Title: Measurements of brain microstructure and connectivity with diffusion MRI

Speaker: Ching-Po Lin (Brain Connectivity Lab, Institute of Neuroscience, National Yang-Ming University)

Time: 2011/7/27, 10:00 am

Venue: Room 1801, East Guanghua Tower

Abstract:
Diffusion MRI is a technique that can probe direction-dependent diffusivity of water molecules to reflect the microstructural tissue status. By detecting intrinsic water molecular Brownian motion non-invasively, direction-dependent diffusivity of water molecules within biological tissues can be applied to reflect the underlying structural integrity. The diffusion probability within each MR voxel is deemed as the neural direction and provides the only in-vivo technique to identify neural pathways. Using 3D tracking algorithm, structural connectivity within human brain can be revealed. Based novel post-processing techniques, specific neural tract and its biological condition can be further identified. Functional dynamics as well as the underlying neural connections between brain regions have been actively studied using functional neuroimage and this novel technique.

 

During the past years, our research effort focused on the development of this novel diffusion imaging technique as well as its applications to neuroscience. In technique development, we have developed new imaging and neural tracking methods, validated the accuracy of diffusion MRI in mapping neural connection, optimized the imaging protocols, and visualized the neuronal network. In neuroscience applications, we have parcellated sub-regions of human corpus callosum based on its connections, identified brain regions that linked to behavioral variations on healthy subjects and patients including neurological disorders, psychiatric disorders, and patients with brain tumor. More recently, correlation between neuronal and functional connectivity has been under actively studied.

 


Seminar 2

Title: Resting State Functional Connectivity
 
Speaker: Bharat Biswal (Department of Radiology, Medical College of Wisconsin, WI)

Time: 2011/7/27, 10:00 am

Venue: Room 1801, East Guanghua Tower

Abstract:
Our lab and others have demonstrated the potential for wide applicability of functional connectivity methods across age groups, and species, regardless of whether it is measured during tasks, rest, sleep or light anesthesia.  The RSFC imaging community has rapidly turned to clinical populations, noting the potential for developing MR-based RSFC approaches as clinically valuable tools, capable of detecting pathological processes and monitoring both disease progression and treatment response.

 

Having provided an initial assessment of test-retest reliability of RSFC measures, the next logical step is to examine “real world” factors likely to impact RSFC measures and obscure test-retest reliability, thus decreasing statistical power.

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