中文  |  English
中心成员
当前位置 >> 首页 >> 中心成员 >> 研究人员
薛磊 研究员
发表时间:2011-11-24 阅读次数:3530次

研究员

复旦大学 生命科学学院
电子邮箱:lxue@fudan.edu.cn
电话:86-21- 55664910
个人主页:N/A

  

背景:
2000.09 - 2005.07  复旦大学生命科学学院神经生物学专业, 获博士学位

1996.09 - 2000.07  复旦大学生命科学学院遗传学专业, 获学士学位

 

奖励与荣誉 :

入选中组部青年千人计划(第三批)

上海浦江人才计划(2012)

 

主要研究方向:

主要从事中枢神经系统突触传递机制研究,着重于突触传递的动力学调控,可塑性,分子细胞机制以及相关计算机建模。主要包括:

1)钙离子调控的胞吐/胞吞机制研究;

2)钙离子通道及突触传递对突触可塑性的影响;

3)神经递质释放回收的计算机模型。 

 

代表性论文:

1. Xue L#, Sheng J, Wu XS, Wu W, Luo FJ, Shin Wonchul, Chiang HC, and Wu LG#. (2013). Most vesicles in a central nerve terminal participate in recycling. Journal of Neuroscience2013 May 15;33(20):8820-6. (#: corresponding author)

2. Xu J, Luo F, Zhang Z, Xue L, Wu XS, Chiang HC, Shin W and Wu LG.(2013). SNARE Proteins Synaptobrevin, SNAP-25, and Syntaxin Are Involved in Rapid and Slow Endocytosis at Synapses. Cell reports, 02 May 2013, doi:10.1016/j.celrep.2013.03.010

3. Xue L, Zhang Z, McNeil B, Luo FJ, Wu XS, Sheng JS and Wu LG. (2012). Voltage-dependent calcium channels at the plasma membrane, but not vesicular channels, couple exocytosis to endocytosis. Cell reports, 1 (6) : 632-638.

4. Sheng JS,He L, Zheng H, Xue L, Luo FJ, Shin W, Sun T and Wu LG. (2012). Calcium-channel number critically influences synaptic strength and plasticity at the active zone. Nature Neuroscience, 15(7), 998–1006.

5. Xue L, McNeil BD, Wu XS, Luo FJ, He L and Wu LG. (2012). A Membrane Pool Retrieved via Endocytosis Overshoot at Nerve Terminals: A Study of Its Retrieval Mechanism and Role. Journal of Neuroscience, 2012 Mar 7; 2(10):3398-404.

6. Xue L and Mei YA. (2011). Synaptic vesicle cycling at the calyx of the Held.  Acta Pharmacological Sinica, 2011 Mar;32(3):280-7.

7. Xue L and Wu LG. (2010). Post-tetanic potentiation is caused by two signaling mechanisms affecting quantal size and quantal content. Journal of Physiology (Lond.)  4987–4994.

8. He L*, Xue L*, Xu J, McNeil B, Bai L, Melicoff E, Adachi R and Wu LG. (2009) Compound vesicle fusion increases quantal size and potentiates synaptic transmission, Nature, 459(7243):93-7. (*: Equal first author)

9. Xue L#, Zhang F, Chen X, Lin J, Shi J. PDZ Protein Mediated Activity-Dependent LTP/LTD Developmental Switch at Rat Retinocollicular Synapses. (2010). American Journal of Physiology, Cell Physiology, 298(6):C1572-82. (#: First author and corresponding author)

10. Wu XS, McNell B, Xu J, Fan JM, Xue L, Melicoff E, Adachi R, Bai L and Wu LG. (2009). Ca2+ and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal. Nature Neuroscience, 12(8):1003-10.

11. Wu XS, Xue L, Mohan R, Paradiso K, Gillis KD, Wu LG. (2007) The origin of quantal size variation: vesicular glutamate concentration plays a significant role. Journal of Neuroscience, 27(11):3046-56.

 

 

版权所有 复旦大学计算系统生物学中心 技术支持:维程互联
地址:上海市邯郸路220号